diff --git a/pyproject.toml b/pyproject.toml
index a48a2c3..743e919 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -38,7 +38,7 @@ dependencies = [
 
 [project.optional-dependencies]
 tfmodisco = [
-    "modisco-lite",
+    "modisco-lite>=2.2.1",
     "tangermeme"
 ]