diff --git a/requirements-gui.txt b/requirements-gui.txt
index 0eb8d96df49..ba664128b4a 100644
--- a/requirements-gui.txt
+++ b/requirements-gui.txt
@@ -1,8 +1,6 @@
 orange-canvas-core>=0.1.21,<0.2a
 orange-widget-base>=4.13.0
 
-PyQt5>=5.12,!=5.15.1  # 5.15.1 skipped because of QTBUG-87057 - affects select columns
-PyQtWebEngine>=5.12
 AnyQt>=0.0.11
 
 pyqtgraph>=0.11.1
diff --git a/requirements-pyqt.txt b/requirements-pyqt.txt
new file mode 100644
index 00000000000..d5d33de1c55
--- /dev/null
+++ b/requirements-pyqt.txt
@@ -0,0 +1,2 @@
+PyQt5>=5.12,!=5.15.1  # 5.15.1 skipped because of QTBUG-87057 - affects select columns
+PyQtWebEngine>=5.12
\ No newline at end of file
diff --git a/setup.py b/setup.py
index b56fdbcda7d..3e9b8cb8eda 100755
--- a/setup.py
+++ b/setup.py
@@ -34,6 +34,13 @@
 except ImportError:
     have_cython = False
 
+try:
+    import PyQt5.QtCore
+    have_pyqt5 = True
+except ImportError:
+    have_pyqt5 = False
+
+is_conda = os.path.exists(os.path.join(sys.prefix, 'conda-meta'))
 
 NAME = 'Orange3'
 
@@ -78,6 +85,12 @@
 
 requirements = ['requirements-core.txt', 'requirements-gui.txt']
 
+# pyqt5 is named pyqt5 on pypi and pyqt on conda
+# due to possible conflicts, skip the pyqt5 requirement in conda environments
+# that already have pyqt
+if not (is_conda and have_pyqt5):
+    requirements.append('requirements-pyqt.txt')
+
 INSTALL_REQUIRES = sorted(set(
     line.partition('#')[0].strip()
     for file in (os.path.join(os.path.dirname(__file__), file)