diff --git a/.circleci/config.yml b/.circleci/config.yml
index 8ca76b3632..2def3efa4c 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -11,6 +11,10 @@ parameters:
     type: string
 
 common: &common
+  parameters:
+    python_exec:
+      type: string
+      default: "python"
   working_directory: ~/repo
   steps:
     - checkout
@@ -28,6 +32,38 @@ common: &common
     - restore_cache:
         keys:
           - cache-v1-{{ arch }}-{{ .Environment.CIRCLE_JOB }}-{{ checksum "setup.py" }}-{{ checksum "tox.ini" }}
+    - run:
+        name: install pypy3 if python_exec is pypy3
+        command: |
+          if [ "<< parameters.python_exec >>" == "pypy3" ]; then
+            sudo apt-get update
+
+            # If .pyenv already exists, remove and reinstall to get latest version
+            if [ -d "$HOME/.pyenv" ]; then
+                echo "Removing existing .pyenv directory..."
+                rm -rf $HOME/.pyenv
+            fi
+            curl https://pyenv.run | bash
+            export PATH="$HOME/.pyenv/bin:$PATH"
+            eval "$(pyenv init --path)"
+            eval "$(pyenv init -)"
+            eval "$(pyenv virtualenv-init -)"
+
+            # Find the latest PyPy version matching the python minor version
+            latest_pypy_version=$(pyenv install --list | grep -E "pypy3\.<< parameters.python_minor_version >>" | grep -v "\-src" | tail -1 | tr -d ' ')
+            echo "Latest PyPy version: $latest_pypy_version"
+
+            # Install the latest PyPy 3.10 version using pyenv if not already installed
+            pyenv install "$latest_pypy_version"
+            pyenv global "$latest_pypy_version"
+
+            # Verify the correct PyPy version is being used
+            pypy3 --version
+
+            # Install pip using the newly installed PyPy version
+            curl https://bootstrap.pypa.io/get-pip.py -o get-pip.py
+            pypy3 get-pip.py
+          fi
     - run:
         name: install dependencies
         command: |
@@ -36,7 +72,7 @@ common: &common
           python web3/scripts/install_pre_releases.py
     - run:
         name: run tox
-        command: python -m tox run -r
+        command: << parameters.python_exec >> -m tox -r
     - save_cache:
         paths:
           - .hypothesis
@@ -145,12 +181,30 @@ jobs:
         type: string
       tox_env:
         type: string
+      python_exec:
+        type: string
+        default: "python"
     <<: *common
     docker:
       - image: cimg/python:3.<< parameters.python_minor_version >>
     environment:
       TOXENV: py3<< parameters.python_minor_version >>-<< parameters.tox_env >>
 
+  common-pypy:
+    parameters:
+      python_minor_version:
+        type: string
+      tox_env:
+        type: string
+      python_exec:
+        type: string
+        default: "pypy3"
+    <<: *common
+    docker:
+      - image: cimg/python:3.<< parameters.python_minor_version >>
+    environment:
+      TOXENV: pypy3<< parameters.python_minor_version >>-<< parameters.tox_env >>
+
   geth:
     parameters:
       python_minor_version:
@@ -228,13 +282,44 @@ workflows:
               python_minor_version: ["8", "9", "10", "11", "12"]
               tox_env: [
                 "lint",
-                "core",
-                "core_async",
-                "ens",
+                "core-pyevm",
+                "core-pyevm_async",
+                "ens-pyevm",
                 "ensip15",
                 "wheel"
               ]
+          python_exec: "python"
           name: "py3<< matrix.python_minor_version >>-<< matrix.tox_env >>"
+      - common:
+          matrix:
+            parameters:
+              # eels only supports 3.10 and above
+              python_minor_version: ["10", "11", "12"]
+              tox_env: [
+                "core-eels",
+                "core-eels_async",
+                "ens-eels",
+                "integration-ethtester-eels"
+              ]
+          python_exec: "python"
+          name: "py3<< matrix.python_minor_version >>-<< matrix.tox_env >>"
+      - common-pypy:
+          matrix:
+            parameters:
+              # eels only supports 3.10 and above; pyenv only has pypy3.10 available
+              python_minor_version: ["10"]
+              tox_env: [
+                "core-eels",
+                "core-eels_async",
+                "ens-eels",
+                "integration-ethtester-eels",
+                "core-pyevm",
+                "core-pyevm_async",
+                "ens-pyevm",
+                "integration-ethtester-pyevm"
+              ]
+          python_exec: "pypy3"
+          name: "pypy3<< matrix.python_minor_version >>-<< matrix.tox_env >>"
       - geth:
           matrix:
             parameters:
@@ -246,7 +331,7 @@ workflows:
                 "integration-goethereum-http_async",
                 "integration-goethereum-legacy_ws",
                 "integration-goethereum-ws",
-                "integration-ethtester"
+                "integration-ethtester-pyevm"
               ]
           name: "py3<< matrix.python_minor_version >>-<< matrix.tox_env >>"
       - docs:
@@ -260,7 +345,6 @@ workflows:
               python_minor_version: ["10", "11", "12"]
           name: "py3<< matrix.python_minor_version >>-windows-wheel"
 
-
   nightly:
     triggers:
       - schedule:
diff --git a/setup.py b/setup.py
index 23cf7781c9..a9260e28d7 100644
--- a/setup.py
+++ b/setup.py
@@ -31,6 +31,10 @@
         "towncrier>=21,<22",
     ],
     "test": [
+        # Note: ethereum-maintained libraries in this list should be added to the
+        # `install_pre_releases.py` script.
+        "eth-tester[py-evm]>=0.11.0b1,<0.13.0b1",
+        "py-geth>=5.0.0",
         "pytest-asyncio>=0.18.1,<0.23",
         "pytest-mock>=1.10",
         "pytest-xdist>=2.4.0",
diff --git a/tox.ini b/tox.ini
index 781be0fb14..e8af27fe42 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,9 +1,10 @@
 [tox]
 envlist=
-    py{38,39,310,311,312}-{ens,core,lint,wheel}-pyevm
-    py{310,311,312}-{ens,core}-eels
-    py{38,39,310,311,312}-integration-{goethereum,ethtester}
+    py{py}{38,39,310,311,312}-{ens,core}-pyevm
+    py{py}{310,311,312}-{ens,core}-eels
+    py{38,39,310,311,312}-integration-{goethereum,ethtester-pyevm}
     py{310,311,312}-integration-ethtester-eels
+    py{38,39,310,311,312}-{lint,wheel}
     docs
     benchmark
     windows-wheel
diff --git a/web3/_utils/module.py b/web3/_utils/module.py
index 63fc151232..bf32e0cdfa 100644
--- a/web3/_utils/module.py
+++ b/web3/_utils/module.py
@@ -27,7 +27,10 @@
 def _validate_init_params_and_return_if_found(module_class: Any) -> List[str]:
     init_params_raw = list(inspect.signature(module_class.__init__).parameters)
     module_init_params = [
-        param for param in init_params_raw if param not in ["self", "args", "kwargs"]
+        param
+        for param in init_params_raw
+        # pypy uses `obj` and `keywords` instead of `self` and `kwargs`, respectively
+        if param not in ["self", "obj", "args", "kwargs", "keywords"]
     ]
 
     if len(module_init_params) > 1: