diff --git a/CHANGELOG.md b/CHANGELOG.md
index b87230e4..9906e803 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -15,6 +15,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ### `Fixed`
 
+- Allow for VEP version 112 to be used and set it to default [#617](https://github.com/nf-core/raredisease/pull/617)
+
 ### Parameters
 
 ### Tool updates
diff --git a/nextflow.config b/nextflow.config
index 33e4c551..3d0893b5 100644
--- a/nextflow.config
+++ b/nextflow.config
@@ -66,7 +66,7 @@ params {
     variant_caller             = 'deepvariant'
 
     // variant annotation
-    vep_cache_version          = 110
+    vep_cache_version          = 112
 
     // sentieon Defaults
     ml_model                   = ''
diff --git a/nextflow_schema.json b/nextflow_schema.json
index 4c4a1acf..4424272b 100644
--- a/nextflow_schema.json
+++ b/nextflow_schema.json
@@ -742,10 +742,9 @@
                 },
                 "vep_cache_version": {
                     "type": "integer",
-                    "default": 110,
+                    "default": 112,
                     "description": "Specify the version of the VEP cache provided to the `--vep_cache` option.",
-                    "fa_icon": "fas fa-align-center",
-                    "enum": [107, 110]
+                    "fa_icon": "fas fa-align-center"
                 }
             }
         },